Alzheimer’s disease (AD) is a slowly progressing, irreversible neurodegenerative brain disease with a long preclinical phase (up to 20 years) and an average clinical duration of 8 to 10 years. The progression of AD is accompanied by changes to the brain that serve as biomarkers of the disease.
Alzheimer’s disease symptoms often start subtly. People with early Alzheimer’s disease (and their families) may mistake the early signs for normal aging and put off going to a doctor.
Disease progression typically spans several stages. These stages include preclinical Alzheimer’s disease, mild cognitive impairment (MCI) due to Alzheimer’s disease, and Alzheimer’s disease dementia varying from mild to severe.
During this stage, clinicians may be able to detect very early features of Alzheimer’s disease compared to other causes of memory loss or other forms of cognitive impairment. These features can be detected using validated tools such as Mini-Cog, General Practitioner Assessment of Cognition (GPCOG), Memory Impairment Screen (MIS), and Montreal Cognitive Assessment (MoCA).7-9
The rate of cognitive decline increases sharply in the years before dementia. Since MCI is the earliest stage of Alzheimer’s disease with observable symptoms, this leaves limited time between diagnosis and dementia—with estimates ranging from 2 to 6 years.1,5,6.
Patients with MCI due to AD have been shown to convert to AD dementia at an annual rate of 31%.
Tips For Caregivers On How To Manage Their Financials While Taking Care Of An Alzheimer Senior Alzheimer’s takes years to spread & show its symptoms. Having a future plan & active conversation with aging parents is an essential act of the preparation for such an adverse life event. Alzheimer's is a slow-progressing disease & can keep […]
Researchers uncover new insights into Alzheimer's disease A new study by Florida State University researchers may help answer some of the most perplexing questions surrounding Alzheimer's disease, an incurable and progressive illness affecting millions of families around the globe. FSU Assistant Professor of Psychology Aaron Wilber and graduate student Sarah Danielle Benthem showed that the […]
The Progression of Alzheimer's Disease Alzheimer’s disease (AD) is a slowly progressing, irreversible neurodegenerative brain disease with a long preclinical phase (up to 20 years) and an average clinical duration of 8 to 10 years. The progression of AD is accompanied by changes to the brain that serve as biomarkers of the disease. Normal aging […]
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